Eva Kleinitz was born in Langenhagen, Lower Saxony. She studied musicology, developmental psychology and Italian literature at the University of Saarland. From 1991, she held the posts of assistant director and facilitator at a number of festivals, among others in Bregenz; Klagenfurt; Avignon; Nîmes; Paris; Strasbourg; Spoleto; Cologne and Schwetzingen. From 1998 as part of her commitment as artistic administrator of the Bregenz Festival she became project leader of "Opera on the Lake" and "Opera in the Festspielhaus", and was responsible for casting, dramaturgy, contracts, opera workshop and the program editing.
From January 2000 Eva Kleinitz ran the artistic operation of the Bregenz Festival until 2003 when she also became personal consultant to the director, Alfred Wopmann. From 2003-2006 she was opera director and deputy director of the Bregenz Festival, under the artistic directorship of David Pountney. From 2006-2010 she became the artistic director for planning and production of the Brussels opera La Monnaie / De Munt. Since 2005, she gives regular guest lectures and workshops at the Showa University of Music in Shinyurigaoka / Kanagawa Prefecture, Japan. She is also a regular juror at international singing competitions. In 2011, she was appointed a member of the board of Opera Europa. Since 2011/12 season, Ms Kleinitz has been opera director and deputy director of the Stuttgart Opera. Since October 2013 is Eva Kleinitz president of Opera Europa. She was appointed general director of Opéra national du Rhin in Strasbourg, Mulhouse and Colmar as of September 2017.